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    Jianping Xu


    【发布日期】:2011-08-09  【来源】:中国农业科学院农业资源与农业区划研究所

    专家姓名:  Jianping Xu
    所在地区:  国外 
    工作单位:  McMaster University  
      
       Associate Professor,
      Department of Biology
      McMaster University, LSB 437
      1280 Main Street West
      Hamilton, ON L8S 4K1
      jpxu@mcmaster.ca
      Phone:  905-525-9140, ext. 27934
      Fax: 905-522-6066

    Research Interests & Activities:
      Ecology and Evolutionary Genetics of Microorganisms
      The overall objective in our research is to understand how microbes evolve. We examine both the patterns of microbial evolution as well as the mechanisms responsible for the observed patterns of evolution. We study microbial populations from the environment, human hosts, clinics, and the laboratory to address a variety of issues such as the rates and effects of spontaneous mutations; the persistence and spread of mutations in natural environments and human populations; and the origins of novel traits, strains and species. Our research uses microbiological, molecular, ecological and quantitative genetic tools.
      Our current and future research projects include:
      (i) The relationship between genetic variation and virulence in human fungal pathogens
      (ii) The genetic mechanisms govern mitochondrial inheritance in Cryptococcus neoformans and its implications for the evolution of organelle inheritance in eukaryotes
      (iii) The roles of spontaneous mutations in the evolution of drug resistance, metabolites, diploidy, and life cycles in microorganisms
      (iv) The genetic and phenotypic consequences of hybridization in microorganisms.

     Funding:
      Research in the Xu Lab is currently being funded by the Natural Sciences and Engineering Research Council (NSERC), Genome Canada, The Premier’s Research Excellence Award (PREA), the Canadian Foundation for Innovation (CFI) and the Ontario Innovation Trust (OIT).

    List of Research Contributions Since 2000:
      Books:
      3. Xu, J. (Editor). 2010. Microbial Population Genetics. Horizon Scientific Press. UK
    2. Xu, J. and Wu, Q. 2006. Essentials of Life Science. 1st Edition. Higher Education Press (Beijing) and Thomson Scientific (Toronto).
    1. Xu, J. (Editor). 2005. Evolutionary Genetics of Fungi. Horizon Scientific Press. UK.
      Contributions to books:
    20. Litvintseva, A.P., J. Xu, and T. G. Mitchell. (In Press) Population Structure and Ecology of Cryptococcus. In Cryptococcus and Cryptococcosis. (Editors J. Heitman, J. Kwon-Chung, J. Perfect, A. Casadevall). ASM Press.
    19. Xu, J., W. Manosuthi, U. Banerjee, L-P Zhu, J.H. Chen, S. Kohno, K. Izumikawa, Y.H. Chen, S. Sungkanuparph, T. S. Harrison, M. Fisher. (In Press) Cryptococcosis in Asia. . In Cryptococcus and Cryptococcosis. (Editors J. Heitman, J. Kwon-Chung, J. Perfect, A. Casadevall). ASM Press.
    18. Xu, J. Microbial ecology in the age of metagenomics. In Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches (Editor Frans J. de Bruijn). Wiley/Blackwell (To be published in 2011)
    17. Luo, Y.Q., K. Lin, and J. Xu. (2010) Comparative Microbial Genomics: Analytical Tools, Population Genetic Patterns and Evolutionary Implications. Chapter 2. In Microbial Population Genetics. (Editor J. Xu), Horizon Scientific Press.
    16. Eardly, B.D. and J. Xu. (2010) Population Genetics of the Symbiotic Nitrogen-fixing Bacteria Rhizobia. Chapter 5. In Microbial Population Genetics. (Editor J. Xu), Horizon Scientific Press.
    15. Xu, J. (2010) Population Genetics in the Age of Metagenomics: Impact on Investigations of Viral, Bacterial, Archaeal and Eukaryotic Microbial Communities Chapter 12. In Microbial Population Genetics. (Editor J. Xu), Horizon Scientific Press.
    14. Xu, J. (2009) Metagenomics and ecosystems biology: conceptual frameworks, tools, and methods. In Metagenomics: Theory, Methods and Applications (Editor Diana Marco), Caister Academic Press.
    13. Xu, J. 2009. Reproduction and sex in microorganisms. Encyclopedia of Life Supporting Systems. UN-UNESCO.
    12. Xu, J. 2008. Using 1-2 individual organisms to address population genetic questions. In Genetic Inheritance Patterns. Nova Publishers.
    11. Xu, J. 2007. Origin, evolution and extinction of asexual fungi: experimental tests using Cryptococcus neoformans. Pp. 461-476. In Sex in Fungi. American Society for Microbiology Press.
    10. Xu, J. Cheng, M., Tan, Q., and Pan, Y. 2005. Molecular population genetics of basidiomycete fungi. In Evolutionary Genetics of Fungi (J. Xu editor). Horizon Scientific Press, England. Pp. 189-220.
    9. Xu, J. 2005. Fundamentals of fungal molecular population genetic analyses. In Evolutionary Genetics of Fungi (J. Xu editor). Horizon Scientific Press, England. Pp. 87-116.
    8. Yan, Z. and Xu, J. 2005. Fungal mitochondrial inheritance and evolution. In Evolutionary Genetics of Fungi (J. Xu editor). Horizon Scientific Press, England. Pp. 221-252.
    7. Xu, J. 2004.  Gene Genealogical analyses of human fungal pathogens. Pp.299-318. “Pathogenic Fungi: Structural Biology and Taxonomy" (editors Gioconda San-Blas, Richard Calderone), Horizon Scientific Press.
    6. Tey*, R., Han*, S, Yan*, Z., Li*, X., Lazzazera*, K., Sun*, S. and Xu, J. 2003. Genotypic and phenotypic diversities of human pathogenic yeasts. Research Advances in Microbiology. Global Research Network. 3: 67-85.
    5. Xu, J. 2003. Molecular population genetics of the commercial mushroom Agaricus bisporus. Research Advances in Microbiology. Global Research Network. 3:35-50
    4. Mitchell, T. G. and Xu, J. 2003. Molecular methods to identify pathogenic fungi. Pp.677-702. Pathogenic Fungi in Humans and Animals (2nd Edition). Editor D. H. Howard.  Marcel Dekker, New York.
    3. Xu, J. and Mitchell, T. G. 2003. Population genetic analyses of medically important fungi. Pp. 703-722. Pathogenic Fungi in Humans and Animals (2nd Edition). Editor D. H. Howard.  Marcel Dekker, New York.
    2. Xu, J. and Mitchell, T. G.  2002. Population genetic analyses of Candida. Pp.55-64.  Chapter 4.  in "Candida and Candidiasis"(3rd edition). Editor R. Calderone, P. Magee, N. Gow, P. Fidel, D. Sanglard, S. Filler, D. Coleman and B. Merz. American Society for Microbiology Press. Washington, D. C.
    1. Xu, J. and Mitchell, T. G. 2002. Strain variation and clonality in species of Candida and Cryptococcus neoformans. Pp. 739-750. Chapter 33.  in Fungal Pathogenesis: Principles and Clinical Applications. Editor Richard Calderone and R. L. Cihlar.  Marcel Dekker, Inc., New York, N.Y.

    Articles in Peer-Reviewed Journals (* Corresponding author)
    66. Maganti H, Yamamura D, Xu J*. Prevalent nosocomial clusters among causative agents for candidemia in Hamilton, Canada. Medical Mycology (In Press)
    65. Cao. CW, Liang L*, Wang WJ, Luo H, Huang SB, Liu DH, Xu J, Henk DA, Fisher MC.  Shared genotype Penicillium marneffei infections in humans and rodents demonstrate common reservoirs of infection in China. Emerging Infectious Diseases (In Press)
    64. Randhawa, H. S.*, T. Kowshik, A. Chowdhary, K. Preeti Sinha, Z. U. Khan, J. Xu; Seasonal variations in prevalence of Cryptococcus neoformans var. grubii and Cryptococcus gattii in decayed wood inside trunk hollows of diverse tree species in north- western India: a retrospective study. Medical Mycology (In Press)
    63. Xu, J*. 2010. Molecular, developmental, and evolutionary genetic studies highlight rapid evolution of genes and genetic systems. Genome 53 (10): 848-852
    62. Niu, QH, Huang XW, Zhang L, Xu J, Yang DM, Wei KB, Niu XM, An ZQ, Bennett JW, Zou CG, Yang JK, and Zhang KQ*. 2010. A Trojan horse mechanism of bacterial pathogenesis against nematodes. PNAS (www.pnas.org/cgi/doi/10.1073/pnas.1007276107)
    61. Li MC, Liang JF, Li YC, Feng B, Yang ZL, James TY, and Xu J*. Genetic diversity of Dahongjun, the commercially important "Big Red Mushroom" from southern China" PLoS ONE 5(5): e10684. doi:10.1371/journal.pone.0010684
    60. Nayak R* and Xu J. 2010. Effects of sertraline hydrochloride and fluconazole combinations on Cryptococcus neoformans and Cryptococcus gattii. Mycology 1: 99-105
    59. Ge SH, Wan Z, Li J, Xu J, Li RY, and Bai FY*. 2010. Correlation between Azole Susceptibilities, Genotypes and ERG11 Mutations in Candida albicans Isolates Associated with Vulvovaginal Candidiasis in China. Antimicrobial Agents and Chemotherapy 54:3126-3131
    58. Fan JY, Guo LY*, Xu J, Luo Y, Michailides TJ. 2010. Genetic Diversity of Populations of Monilinia fructicola (Fungi, Ascomycota, Helotiales) from China. J Eukaryotic Microbiology 57: 206-212.
    57. Liang, J. F., Yang, Z. L.*, Xu J and Z-W Ge. 2010. Two new unusual Leucoagaricus species (Agaricaceae) from tropical China with blue-green staining reactions. Mycologia 102: 1141-1152
    56. Wu, J. R., H.C. Ma,M. LÜ, S.F. Han, Y.Y. Zhu, H. Jin, J.F. Liang, L. Liu, and J. Xu*. 2010.  Rhizoctonia fungi enhance the growth of the endangered orchid Cymbidium goeringii. Botany 88: 20-29
    55. Skosireva, I., T. Y. James, S. Sun, and J. Xu*. 2010. Mitochondrial inheritance in haploid x non-haploid crosses in Cryptococcus neoformans. Current Genetics56:163-176
    54. Xu, J.*, Cadorin, M., Liang, Y-J, and Yang, Z.L.. 2010. DNA-based geographical typing of the gourmet mushroom Tricholoma matsutake traded in China. Mycoscience 51:248–251. DOI 10.1007/s10267-009-0024-0)
    53. Wang, Q.M.. J. Xu, H.M. Wang, J. Li, F.Y. Bai*. 2009. Torulaspora quercuum sp. nov. and Candida pseudohumilis sp. nov., novel yeasts from human and forest habitats. FEMS Yeast Research 9:1322-1326
    52. Guo, H., S. Sun, B. Eardly, T. Finan, and J. Xu*, 2009. Genome variation in the symbiotic nitrogen-fixing bacterium Sinorhizobium meliloti. Genome 52:862-875
    51. Liang*, J. F., J. Xu, and Z. L. Yang. 2009. Divergence, dispersal and recombination in Lepiota cristata from China. Fungal Diversity 38:105–124
    50. Xu, J*., Z. Yan, and H. Guo. 2009. Divergence, hybridization, and recombination in the mitochondrial genome of the human pathogenic yeast Cryptococcus gattii. Molecular Ecology 18: 2628-2642
    49. Li, M. and Xu, J*. 2009. Molecular ecology of ectomycorrhizal fungi: molecular markers, genets and ecological importance. Acta Botanica Yunnanica 31: 193-209
    48. Sun, S. and J. Xu*. 2009. Chromosomal rearrangements between serotype A and D strains in Cryptococcus neoformans. PLoS ONE. 4(5): e5524
    47. Sha, T., J. Xu*, M. G. Palanichamy, H.-B. Zhang, T. Li, Z.-W. Zhao, Y.-P. Zhang*. 2008. Genetic diversity of an endemic gourmet mushroom Thelephora ganbajun from southwestern China. Microbiology 154, 3460-3468
    46. Ciccotelli*, W., Haider S., and Xu, J. 2008. A traveler in time: phylogenetic analysis diagnoses the first case of reactivated sub-acute disseminated African histoplasmosis in an immunocompromised host from Tanzania. Canadian Journal of Infectious Diseases and Medical Microbiology. 19: 313-315
    45. Ásmundsdóttir, L. R., Erlendsdóttir, H., Haraldsson, G., Guo, H., Xu, J., Gottfredsson*. M. 2008. Molecular epidemiology of candidemia: Evidence for smoldering nosocomial clustering. Clinical Infectious Diseases 47:17-24
    44. Hiremath, S. S., A. Chowdhary, T. Kowshik, H. S. Randhawa, S. Sun and J. Xu* 2008 Long-distance dispersal and recombination in environmental populations of Cryptococcus neoformans var. grubii from India. Microbiology 154: 1513-1524
    43. Randhawa, H. S., T. Kowshik, A. Chowdhary, K. Preeti Sinha, Z. U. Khan, S. Sun and J. Xu, 2008 The expanding host tree species spectrum of Cryptococcus gattii and Cryptococcus neoformans and their isolations from surrounding soil in India. Medical Mycology 18: 1-11
    42. Shahid, M., Han, S., Yoell, H., and Xu, J*. 2008. Fitness distribution and transgressive segregation across 40 environmental conditions in a hybrid progeny population of the human pathogenic yeast Cryptococcus neoformans. Genome 51:272-281
    41. Xu, J*., Sha, T., Li, Y.-C., Zhao, Z.-W., and Yang, Z.- L. 2008. Recombination and genetic differentiation among natural populations of the ectomycorrhizal mushroom Tricholoma matsutake from southwestern China. Molecular Ecology 17: 1238-1247
    40. Sun, S., and Xu, J*. 2007. Genetic analyses of a hybrid cross between serotypes A and D strains of the human pathogenic fungus Cryptococcus neoformans. Genetics 177:1475-1486
    39. Li, G., Zhang, K*., Xu, J., Dong, J., and Liu, Y. 2007. Nematicidal substances from fungi. Recent Patents in Biotechnology 1: 212-233
    38. Wang, H., Guo, H., Sun, S., and Xu, J*. 2007. Abundant sequence variation around the mitochondrial origin of replication in the human opportunistic yeast pathogen Candida albicans from a tropical island in China. Fungal Genetics and Biology 44:991-1001
    37. Wang, H., Wang, Y., Chen, J., Zhan, Z., Li, Y., and Xu, J*. 2007. Oral yeast flora and their ITS sequence diversity among a large cohort of medical students in Hainan, China. Mycopathologia. 164:65-72
    36. Xu, J*., Guo, H., and Yang, Z-L*. 2007. Single nucleotide polymorphisms in the ectomycorrhizal mushroom Tricholoma matsutake. Microbiology 153:2002-2012 (cover photo)
    35. Yan, Z., Hull, C. M., Sun, S., Heitman, J., and Xu, J*. 2007. The mating type-specific homeodomain genes SXI1a and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Current Genetics 51:187-195
    34. Yan, Z., Sun, S., Shahid, M., and Xu, J*. 2007. Environment factors can influence mitochondrial inheritance in the fungus Cryptococcus neoformans. Fungal Genetics and Biology 44:315-322
    33. Xu, J. 2006. Evolution of microbial pathogens. Emerging Infectious Diseases. 8:1306-1307
    32. Randawa HS*, Kowshik T, Preeti Sinha K, Chowdhary A, Khan ZU, Yan Z, Xu J, Kumar A. 2006. Distribution of Cryptococcus gattii and Cryptococcus neoformans in decayed trunk wood of Syzygium cumini trees in north-western India. Medical Mycology. 44:623-630
    31. Sun, S., Guo, H., and Xu, J*. 2006. Multiple gene genealogical analyses reveal both common and distinct population genetic patterns among replicons in the nitrogen-fixing bacterium Sinorhizobium meliloti. Microbiology. 152:3245-3259

    30. Xu, J. 2006. Extracting haplotypes from diploid organisms. Current Issues in Molecular Biology. 8:113-122
    29. Xu, J. 2006. Fundamentals of fungal molecular population genetic analyses. Current Issues in Molecular Biology. 8:75-89
    28. Lan, L. and Xu, J*. 2006. Multiple gene genealogical analyses suggest divergence and recent clonal dispersal in the opportunistic human pathogen Candida guilliermondii. Microbiology. 152:1539-1549
    27. Xu, J. 2006. Microbial ecology in the age of genomics and metagenomics: concepts, tools and recent advances. Molecular Ecology 15:1713-1731
    26. Xu, J. 2005. Cost of interacting with sexual partners in a facultative sexual microbe.  Genetics. 171:1597-1604
    25. Xu, J. 2005. The inheritance of organelle genes and genomes: patterns and mechanisms.  Genome. 48:951-958
    24. Kidd, S.E., Guo, H., Bartlett, K., Xu, J., Kronstad, J. W*. 2005. Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas.  Eukaryotic Cell 4: 1629-1638
    23. Guo, H., Sun, S., Finan, T.M. and Xu, J*. 2005. Novel DNA sequences from natural strains of the nitrogen-fixing symbiotic bacterium Sinorhizobium meliloti.  Applied and Environmental Microbiology. 71:7130-7138
    22. Xu, J. 2004. Genotype-environment interactions of spontaneous mutations affecting vegetative fitness in the human pathogenic fungus Cryptococcus neoformans. Genetics 168:1177-1188.
    21. Yan, Z, Hull, C. M., Heitman, J., Sun, S. and Xu, J*. 2004. SXI1a controls uniparental mitochondrial inheritance in Cryptococcus neoformans.  Current Biology. 14:R743-R744.
    20. Xu, J. 2004. The prevalence and evolution of sex in microorganisms. Genome 47:775-780
    19. Xu, J*. and Mitchell, T. G. 2003. Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans.  Microbiology. 149:2147-2154.
    18. Montour, L. Tey, R. and Xu, J*. 2003. Isolation of Candida dubliniensis in an aboriginal community in Ontario, Canada.  Journal of Clinical Microbiology. 41:3423-3426.
    17. Gottfredsson, M*., Vredenburgh, J., Xu, J., Schell, W. A., Perfect, J. R. 2003. Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation. Cancer. 98:24-30.
    16. Yan, Z. and Xu, J*. 2003. Mitochondria are transmitted from MATa parent in sexual crosses of the human pathogenic fungus Cryptococcus neoformans.  Genetics 163, 1315-1325.
    15. Xu, J. and Mitchell, T. G*. 2003. Geographic differences in human oral yeast flora. Clinical Infectious Diseases 36: 221-224.
    14. Li, X., Yan, Z., and Xu, J*. 2003. Quantitative variation in biofilms among strains in natural populations of Candida albicans. Microbiology 149: 353-362.
    13. Khan, Z.U*., Al-Anezi, A. A., Chandy, R. and Xu, J. 2003.  Disseminated cryptococcosis in an AIDS patient caused by a canavanine-resistant strain of Cryptococcus neoformans var. grubii. Journal of Medical Microbiology 52: 271-275.
    12. Xu, J*. 2002. Estimating the spontaneous mutation rate of loss of sex in the human pathogenic fungus Cryptococcus neoformans.  Genetics 162:1157-1167.
    11. Xu, J*. 2002. Mitochondrial DNA polymorphisms in the human pathogenic fungus Cryptococcus neoformans.  Current Genetics 41:43-47.
    10. Kam, A., and Xu, J*. 2002. Diversity of commensal yeasts from within and between healthy hosts.  Diagnostic Microbiology and Infectious Diseases 43:19-28.
    9. Xu, J*., Desmerger, C., and Callac, P. 2002. Fine scale genetic analyses reveal unexpected spatial-temporal heterogeneity in two natural populations of the commercial mushroom Agaricus bisporus. Microbiology 148:1253-1262.
    8. Yan, Z., Li X, and Xu, J*. 2002. Geographic distribution of mating type alleles of Cryptococcus neoformans in four areas of the United States.  Journal of Clinical Microbiology 40:965-972.
    7. Xu, J*., Luo, G., Vilgalys R., Brandt, M. E., and Mitchell, T. G. 2002. Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD.  Microbiology 148:203-212.
    6. Forche, A., Xu, J., Vilgalys R., and Mitchell, T. G*. 2001. Development and characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms (AFLP) and other markers.  Fungal Genetics and Biology.  31:189-203.
    5. Xu, J*., Onyewu, C., Yoell, H. J., Ali, R. Y., Vilgalys, R., and Mitchell, T. G. 2001. Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 45:420-427.
    4. McEwen JG*, Taylor JW, Carter D, Xu J, Felipe MSS, Vilgalys R, Mitchell TG, Kasuga T, White T, Bui T, Soares CMA.  2000. Molecular typing of pathogenic fungi. Medical Mycology 38(sppl 1):189-197.
    3. Xu, J. Vilgalys, R., and Mitchell, T. G*. 2000.  Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. Molecular Ecology.  9:1471-1481.
    2. Xu, J., Ramos, A., Vilgalys, R. and Mitchell, T. G*. 2000. Clonal and spontaneous origins of fluconazole resistance in Candida albicans. Journal of Clinical Microbiology.  38:1214-1220.
    1. Xu, J., Ali, R., Gregory, D., Amick, D., Lambert, S., Yoell, H., Vilgalys, R. and Mitchell, T. G*. 2000. Uniparental mitochondrial transmission in sexual crosses in Cryptococcus neoformans. Current Microbiology.  40:269-273.

     http://www.biology.mcmaster.ca/faculty/xu/xu.htm

     
     
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