熊浩仲; 谢小梅; 苏明声; 庄毅; 周雪娥; 张普照; 舒任庚
江西中医学院菌物药研究中心; 江西中医学院现代中药制剂教育部重点实验室
【中文摘要】 采用小鼠肉瘤(S180)移植性肿瘤模型,观察灵雷菌质乙酸乙酯部位、正丁醇部位、石油醚部位和水部位提取物的肿瘤抑制作用,并测定小鼠的胸腺指数及脾脏指数。结果表明所有的提取物都呈现出明显的抑瘤效果,抑瘤率均大于35%,其中部分正丁醇部位的抑瘤率达到了68.88%。抑瘤效果由弱至强的顺序为石油醚部位<水部位<乙酸乙酯部位<正丁醇部位,而胸腺指数与脾脏指数则显示只有乙酸乙酯部位组有较明显的免疫抑制效果。双向性固体发酵可降低雷公藤的毒性,尤其正丁醇部位和水部位的毒性可能较弱。
【英文摘要】 The transplanting tumor model of mice sarcoma S180 was used to observe the anti-tumor effect of fermentation substance on Tripterygium, such as ethyl acetate part, n-butyl alcohol part, petroleun ether part and water part, and the thymus index and spleen index of mice had been measured. The results showed that all extracts had a significant inhibitory effect on tumor. The tumor inhibitory rates were all above 35% and the n-butyl alcohol part reached 68.88%. The inhibitory effect on tu- mor from low to high is petroleun ether part<water part<ethyl acetate part<n-butyl alcohol part. The thymus index and spleen index indicated that only ethyl acetate part had relatively obvious immunosuppressive effect. The bi-directional solid fermentation can reduce the toxicity of Tripterygium, especially, the n-butyl alcohol part and water part have less toxicity than others.
【中文关键词】 双向性固体发酵; 雷公藤; 灵雷菌质; 提取物; 抗肿瘤作用
【英文关键词】 Bi-directional solid fermentation; Triperygium wilfordii Hook.; Fermentation substance on Tripterygium; Extract; Anti-tumor effect
【基金】科技部国际合作项目(雷公藤固体发酵减毒持效的研究),项目编号:2006DFA33060;; 江西省卫生厅中医药科研计划(G菌固体发酵雷公藤减毒持效作用的功能酶系研究),项目编号:赣卫中字[2007]20号。
【文献出处】 中国食用菌,Edible Fungi of China,编辑部邮箱,2009年01期 【DOI】CNKI:SUN:ZSYJ.0.2009-01-021