Intercalative Nanohybride of Cordycepin in Layered Double Hydroxide
Abstract：A novel negatively charged cordycepin-[Mg-Al-NO] nanohybrid has been prepared by ion-exchanged method.Results of TEM, PXRD and FT-IR spectroscopy confirmed that cordycepin could be intercalated into [Mg-Al-NO3] interlayers as the charge-compensating species.Preliminary result show that the new bioinorganic nanohybrid may be used as a novel inorganic pharmaceutically active compounds reservoir or carrier.b.
Keywords：cordycepin; layered double hydroxide; nanohybrid; intercalate
虫草素LDH插层纳米复合体
杨亲正 罗珊珊 凌建亚 李彦 张长铠
摘 要：通过离子交换反应制备了一种新型虫草素层状双氢氧化物纳米复合体. 透射电镜、X-衍射和红外光谱分析结果表明,带负电的虫草素中和无机层片电荷而插层到镁铝层状双氢氧化物[Mg-Al-NO3]中.实验结果显示,通过简单的离子交换,可制得新型生物有机纳米复合体,该类纳米复合体将有可能成为生物活性分子的贮存库或载体.
关键词：虫草素; 层状双氢氧化物; 纳米复合体; 插入
CLC Number：S567.3+5
Author Resume：Yang Qinzheng,mail,born in 1975,Ph.D..Address:State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100.张长铠,Corresponding author
Author Unit：杨亲正（山东大学微生物技术国家重点实验室,济南,250100）
罗珊珊（山东大学微生物技术国家重点实验室,济南,250100）
凌建亚（山东大学微生物技术国家重点实验室,济南,250100）
李彦（山东大学微生物技术国家重点实验室,济南,250100）
张长铠（山东大学微生物技术国家重点实验室,济南,250100）
References：
［1］Xu Z P , Zeng H C.Abrupt structural transformation in hydrotalcite-like compounds Mg1-xAlx(OH)2(NO3)x*nH2O as a continuous function of nitrate anio.J Phys Chem B ,2001, 105: 1743.
［2］Legrouri A , Badreddine M, Barroug A, et al. Influence of pH on the synthesis of the Zn-Al-nitrate layered double hydroxide and the exchange of nitrate by phosphate ions. J P Besse,J Mater Sci Lett,1999, 18:1077
［3］Choy J H, Kwak S Y , Park J S, et al.Intercalative nanohybrids of nucleoside monophosphates and DNA in layered metal hydroxide. J Am Chem Soc,1999,121:1399
［4］Zhao H T, Vance G F. Intercalation of carboxymethyl-cyclodextrin into magnesium-aluminum layered double hydroxide. J Chem Soc DaltonTrans,1997,11:1961
［5］Ahn Y J, Park S J ,Lee S G , et al. Cordycepin selective growth inhibitor derived from liquid culture of cordyceps militaris against clostridium spp. J Agric Food Chem,2000, 48:2744
［6］Suger A M ,Mccaffrey R P .Antifungal activity of 3'-deoxyadenosine (cordycepin). Agents Chemother, 1998, 42:1424
［7］Mueller W E G, Weiler B E, R, Charubala Ret al.Cordycepin analogues of 2'5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochem Wash,1991, 30:2027
［8］Grahn B , Loevtrup-Rein H .The effect of cordycepin on nuclear RNA synthesis in nerve and glial cells. Acta Physiol Scand,1971, 82:28
［9］Yang Q Z , Zhan C G, Sun D J ,et al.Studies on Synthesis and Properties of Mg-Al-Nitrate Layered Double Hydroxide .Acta Chimica Sinica,2002, 9:1712
［10］Ling J Y , Sun Y J, Zhang H,et al.Measurement of cordycepin and adenosine in stroma of cordyceps sp. By capillary zone electrophoresis.J BiosBioe, 2002, 94:371
华中农业大学学报
JOURNAL OF HUAZHONG AGRICULTURAL UNIVERSITY
2004 Vol.23 No.1
